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2025

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Wilson EN, Umans J, Swarovski MS, Minhas PS, Mendiola, J.H., Midttun Ø, Ulvik A, Shahid-Besanti M, Linortner P, Mhatre SD, Wang Q, Channappa D, Corso NK, Tian L, Fredericks CA, Kerchner GA, Plowey ED, Cholerton B, Ueland PM, Zabetian CP, Gray NE, Quinn JF, Montine TJ, Sha SJ, Longo FM, Wolk DA, Chen-Plotkin A, Henderson VW, Wyss-Coray T, Wagner AD, Mormino EC, Aghaeepour N, Poston KL, Andreasson KI   “Parkinson’s disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction”  npj Parkinson’s Disease. 11(1):96 (2025). PMID: 40287426

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Oh HS, Urey DY, Karlsson L, Zhu Z, Shen Y, Farinas A, Timsina J, Duggan MR, Chen J, Guldner IH, Morshed N, Yang C, Western D, Ali M, Le Guen Y, Trelle A, Herukka SK, Rauramaa T, Hiltunen M, Lipponen A, Luikku AJ, Poston KL, Mormino E, Wagner AD, Wilson EN, Channappa D, Leinonen V, Stevens B, Ehrenberg AJ, Gottesman RF, Coresh J, Walker KA, Zetterberg H, Bennett DA, Franzmeier N, Hansson O, Cruchaga C, Wyss-Coray T  "A Cerebrospinal Fluid Synaptic Protein Biomarker for Prediction of Resilience Versus Decline in Alzheimer's Disease"  Nature Medicine.  31:1592-1603 (2025). PMID: 40164724

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​Sheng J, Trelle AN, Romero A, Park J, Tran TT, Sha SJ, Andreasson KI, Wilson EN, Mormino EC & Wagner AD  "Top-Down Attention and Alzheimer's Pathology Affect Cortical Selectivity During Learning, Influencing Episodic Memory in Older Adults"  Science Advances. 11(24) (2025). PMID: 40512843​

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Ali M, Shen Y, Do A, Wang L, Western D, Liu M, Beric A, Budde J, Gentsh J, Schindler S, Morris J, Holtzman D, Ferneandez M, Ruis A, Alvarez I, Aquilar M, Pastor P, Rutledge J, Oh H, Wilson EN, Le Guen Y, Khalid R, Robins C, Pulford D, Ibanez L, Wyss-Coray T, Ju Y, Cruchaga C.  “Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer’s disease” Neuron. 113(9):1363-1379 (2025). PMID: 40088886.

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Grandke F, Fehlmann T, Kern F, Gate DM, Wolff TW, Leventhal O, Channappa D, Hirsh P, Wilson EN, Meese E, Liu C, Shi Q, Flotho M, Lil Y, Chen C, Yu Y, Xu J, Junkin M, Wang Z, Wu T, Liu L, Hou Y, Andreasson KI, Gansen JS, Mass E, Poston KL, Wyss-Coray T, Keller A  “A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration” Nature Communications. 16 (1): 1965 (2025). PMID: 40000636

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Winer, JR, Vossler H, Young CB, Smith V, Romero A, Shahid-Besanti M, Abdelnour C, Wilson EN, Anders D, Pacheco Morales A, Andreasson KI, Yutsis MV, Henderson VW, Davidzon GA, Mormino EC, Poston KL  “18F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease” Brain Communications. 7(1) (2025). PMID: 39741783

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Trelle AN, Young CB, Vossler H, Ramos Benitez J, Cody KC,  Swarovski MS, Le Guen Y, Kasireddy NM, Feinstein I, Butler III RR, Channappa D, Romero A, Park J, Shahid-Besanti M,  Corso NK, Chau K, Smith AN, Skylar-Scott I, Yutsis MV, Fredericks CA, Tian L, Younes K, Kerchner GA, Deutsch GK, Davidzon G, Sha SJ, Henderson VW, Longo FM, Greicius MD, Wyss-Coray T, Andreasson KI, Poston KL, Wagner AD, Mormino EC & Wilson EN  “Plasma Aβ42/Aβ40 is sensitive to cerebral Aβ accumulation across the Alzheimer’s disease spectrum”. Alzheimer’s & Dementia. 21(2): e14442 (2025). PMID: 39713875 

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​2024

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Wilson EN, Wang C, Swarovski MS, Zera KA, Ennerfelt HA, Wang Q, Chaney A, Gauba E, Ramos Benitez J, Le Guen Y, Minhas PS, Panchal M, Tan YJ, Blacher E, Iweka CA, Cropper H, Jain P, Liu Q, Mehta SS, Zuckerman AJ, Xin M, Umans J, Huang J, Durairaj AS, Serrano GE, Beach TG, Greicius MD, James ML, Buckwalter MS, McReynolds MR, Rabinowitz JD & Andreasson KI “TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer’s disease mouse models”

Nature Neuroscience. 27, 873-885 (2024). PMID: 38539014

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Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GS, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH & Andreasson KI " Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies" Science.  385(6711):eabm6131 (2024). PMID: 39172838

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Western D, Timsina J, Wang L, Wang C, Yang C, Phillips B, Wang Y, Liu M, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey AI, Morris JC, Perrin RJ, Ruiz A, Marquie M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson EN, Le Guen Y, Reus LM, Tijms B, Visser PJ, van der Lee SJ, Pijnenburg YAL, Teunissen CE, del Campo Milan M, Alvarez I, Dominantly Inherited Alzheimer Network (DIAN), the Alzheimer's Disease Neuroimaging Initiative (ADNI), Greicius MD, Pastor P, Pulford DJ, Ibanez L, Wyss-Coray T, Sung YJ & Cruchaga C "Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicated causal proteins for Alzheimer's disease"  Nature Genetics.  56, 2672-2684 (2024). PMID: 39538825 

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Abdelnour C., Young C.B., Shahid-Besanti M., Smith A., Wilson E.N., Ramos Benitez J., Vossler H., Plastini M.J., Winer J.R., Kerchner G.A., Cholerton B., Andreasson K.I., Henderson V.W., Yutsis M., Montine T.J., Tian L., Mormino E.C., & Poston K.L. “Plasma pTau181 reveals a pathological signature that predicts cognitive outcomes in Lewy body disease” Annals of Neurology. PMID: 38888142

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Plastini, M.J., Abdelnour, C., Young C.B., Wilson, E.N., Shahid-Besanti, M., Lamoureux, J., Andreasson, Ki., Kerchner, G.A., Montine, T.J., Henderson, V.W., Poston, K.L. “Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer’s disease spectra” Annals of Clinical and Translational Neurology 11(5), 1197-1210 (2024).  PMID: 38436140

Guilliot, S., Wilson, E.N., Touchon, J., Soto, M.E., “Nanolithium, a new treatment approach to Alzheimer’s disease: a review of existing evidence and clinical perspectives”  The Journal of Prevention of Alzheimer’s Disease 11(2), 428-434 (2024). PMID: 38374749

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Abiose, O., Rutledge, J., Moran-Losada, P., Belloy, M.E., Wilson E.N., He, Z., Trelle, A.N., Channappa, D., Romero, A., Park, J., Sha, S., Greicius, M., Andreasson, K.I., Poston, K.L., Henderson, V.W., Wagner, A.D., Wyss-Coray, T., Mormino, E.C. “Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes” Alzheimer’s & Dementia 20(3):1851-1867 (2024)  PMID: 38146099

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2023

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Oh, H., Rutledge, J., Pavlovics, R., Nachun, D., Pálovics, R., Abiose, O., Moran-Losada, P., Channappa D., Urey, D.Y., Kim, K., Sung Y.J., Wang, L., Timsina, J., Western, D., Liu, M., Kohlfeld, P., Budde, J., Wilson, E.N., Guen, Y., Maurer, T.M., Haney, M., Yang, A.C., He, Z., Greicius, M.D., Andreasson, K.I., Sathyan, S., Weiss, E.F., Milman, S., Barzilai, N., Cruchaga, C., Wagner, A.D., Mormino, E., Lehallier, B., Henderson, V.W., Longo, F.M., Montgomery, S.B., Wyss-Coray, T. “Organ-specific aging signatures in the plasma proteome track health and disease”  Nature  624(7990):164-172 (2023). PMID: 38057571

Chaney, A.M., Cropper, H.C., Jain, P., Wilson, E., Simonetta, F., Johnson, E.M., Alam, I.S., Patterson, I.T.J., Swarovski, M., Stevens, M.Y., Wang, Q., Azevedo, C., Nagy, S.C., Ramos Benitez, J., Deal, E.M., Vogel, H., Andreasson, K.I., & James., M.L. “PET imaging of TREM1 identifies CNS-infiltrating myeloid cells in a mouse model of multiple sclerosis,” Science Translational Medicine 15(702) (2023). PMID: 37379371

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2022

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Wilson, E.N., Young, C.B., Ramos Benitez, J., Swarovski, M.S., Feinstein, I., Vandijck, M., Le Guen, Y., Kasireddy, N.M.,  Shalid, M., Corso, N.K., Wang, Q., Kennedy, G., Trelle, A., Lind, B., Channappa, D., Belnap, M., Ramirez, V., Skylar-Scott, I., Younes, K., Yutsis, M.V., Le Bastard, N., Quinn, J.F., van Dyck, C.H., Nairn, A., Fredericks, C.A., Tian, L., Kerchner, G.A., Montine, T.J., Sha, S.J., Davidzon, G., Henderson, V.W., Longo, F.M., Greicius, M.D., Wagner, A.D., Wyss-Coray, T., Poston, K.L., Mormino, E.C. & Andreasson, K.I. “Performance of a Fully-Automated Lumipulse Plasma Phospho-Tau181 Assay for Alzheimer’s Disease,” Alzheimer’s Research & Therapy 14, 172 (2022). PMID: 36371232

Arnold, M.R., Coughlin, D.G., Brumbach, B.H., Smirnov, D.S., Concha-Marambio, L., Farris, C.M., Ma, Y., Kim, Y., Wilson, E.N., Kaye, J.A., Hiniker, A., Woltjer, R.L., Galasko, D.R., Quinn, J.F. “α-Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α-Synuclein in the Context of Co-Pathology and Non-LBD Diagnoses,” Annals of Neurology (2022). PMID: 35808984

Shuken, S.R., Rutledge, J., Iram, T., Moran Losada, P., Wilson, E.N., Andreasson, K.I., Leib, R.D., Wyss-Coray, T., “Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures,” Nature Aging 2, 379-388 (2022). PMID: 36741774

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2021 & previous

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Wilson, E.N., Andreasson, K.I. “TAM-ping Down Amyloid in Alzheimer’s Disease,” Nature Immunology 22, 543-544 (2021). PMID: 33859407.

Feinstein, I., Wilson, E.N., Swarovski, M.S., Andreasson, K.I., Angst, M.S., Greicius, M.D., “Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Non-Cardiac Surgery,” JAMA Neurology 78(11), 1407-1409 (2021). PMID: 34543578 

Trelle, A.N., Carr, V.A., Wilson, E.N., Swarovski, M.S., Hunt, M.P., Toueg, T.N., Tran, T.T., Channappa, D., Corso, N.K., Thieu, M.K., Jayakumar, M., Nadiadwala A., Guo, W., Tanner, N.J., Bernstein, J.D., Litovsky, C.P., Guerin, S.A., Khazenzon, A.M., Harrison, M.B., Rutt, B.K., Deutsch, G.K., Chin, F.T., Davidzon, G.A., Hall, J.N., Sha, S.J., Fredericks, C.A., Andreasson, K.I., Kerchner, G.A., Wagner, A.D., Mormino, E.C., “Association of CSF Biomarkers with Hippocampal-dependent Memory in Preclinical Alzheimer Disease,” Neurology 96 (10), 1470-1481 (2021). PMID: 33408146

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Wilson EN, Swarovski MS, Linortner P, Shahid M, Zuckerman, A.J., Wang, Q., Channappa, D., Minhas, P.S., Mhatre, S.D., Plowey, E.D., Quinn, J.F., Zabetian, C.P., Tian, L., Longo, F.M., Cholerton, B., Montine, T.J., Poston, K.L., Andreasson, K.I., “Soluble TREM2 is elevated in Parkinson’s disease subgroups with elevated CSF tau,” Brain 143 (3), 932-943 (2020). PMID: 32065223.     

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Wilson, E.N., Do Carmo, S., Hall, H., Welikovitch, L.A., Aquilar, L.F., Foret, M.K., Iulita, M.F., Jia, D.T., Allard, S., Emmerson, J.T., Ducatenzeiler, A., Cuello, A.C., “NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats,” Journal of Alzheimer’s Disease 73 (2), 723-739 (2020). PMID: 31868669.

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Liu, Q., Johnson, E., Lam, R.K., Wang, Q., Ye, H.B., Wilson, E.N., Minhas, P.S., Liu, L., Swarovski, M., Wang, J., Mehta, S.S., Rabinowitz, J., Shamloo, M., Mueller, C., James, M., Andreasson, K.I., “Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity,” Nature Immunology; 20 (8), 1023-1034 (2019). PMID: 31263278.

Liu, Q., Liang, X., Wang, Q., Wilson, E.N., Lam, R.K., Wang, J., Wong, W., Tsai, C.A., Pan, T., Larkin, P.B., Shamloo, M., Andreasson, K.I., “Activation of neuronal and myeloid PGE2 EP2 signaling worsens cerebral injury in a model of stroke,” Proceedings of the National Academy of Science 116 (20), 10019-10024 (2019). PMID: 31036664.

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Wilson, E.N., Do Carmo, S., Iulita, M.F., Hall, H., Austin, G.L., Jia, D.T., Malcolm, J.C., Foret, M. K., Marks, A.R., Butterfield, D.A., Cuello, A.C., “Microdose lithium NP03 diminishes pre-plaque oxidative damage and neuroinflammation in Alzheimer rats,” Current Alzheimer Research 15 (13), 1220-1230 (2018). PMID: 30182855.           

Iulita MF, Bistué Millón MB, Pentz R, Aguilar, L.F., Allard, S., Do Carmo, S., Michalski, B., Wilson, E.N.,  Ducatenzeiler, A., Fahnestock, M., Bruno, M. A., and Cuello, A.C., “Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer’s disease,” Neurobiology of Disease 108, 307-323 (2017). PMID: 28865749.

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Wilson EN, Do Carmo S, Iulita MF, Hall H, Ducatenzeiler A, Marks AR, Allard S, Jia D, Windheim J & Cuello AC, “BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology,” Translational Psychiatry 7, 1-10 (2017). PMID: 28763060.

Wilson EN, Abela AR, Do Carmo S, Allard S, Marks AR, Welikovitch LA, Ducatenzeiler A, Chudasama Y & Cuello AC, “Intraneuronal amyloid beta accumulation disrupts hippocampal CRTC1-dependent gene expression and cognitive function in a rat model of Alzheimer disease,” Cerebral Cortex 27, 1501-1511 (2017). PMID: 26759481. 

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Qi Y, Klyubin I, Harney SC, Hu N, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, Furhmann M, Ashe KH, Cuello AC & Rowan MJ, “Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents,” Acta Neuropathologica Communications 24, 1-15 (2014). PMID: 25540024.

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